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Heres how specific conditions can impact the use of B12 shots: Heart Disease: While B12 is essential for overall health, excessive amounts of vitamin B12 in the body may sometimes cause an increase in certain heart disease risk markers, particularly for individuals with pre-existing cardiovascular conditions
& Boban Blagaic, A
2018 Jan 1;41(Supplement 1):S7385
If switching the route of administration and dosage don't help, you may also have like a substrate issue