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2.1 Inclusion criteria (1) The study design should be conducted in rats, mice, or clinical patients

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Phentermine levels can accumulate in patients with kidney disease, increasing the risk of adverse effects

Response: We thank the commenter for their input and will consider the suggestion for future rulemaking

Clinical trials show dose-dependent weight loss, with 2.4 mg weekly producing greater losses than 1 mg

Hypoxic induction of vascular endothelial growth factor is selectively impaired in mice carrying the mutant SOD1 gene