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A., Li, B

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A double-blind, placebo-controlled trial in 95 patients with irritable bowel syndrome or inflammatory bowel disease and normal B12 levels found no significant improvements in fatigue, although B12 levels increased in the B12 group who received 1000 g per day per os (p.o.) for 8 weeks (form not reported)

The American Diabetes Association's Standards of Care acknowledge the ongoing uncertainty, noting that while pancreatitis has been reported with GLP-1 receptor agonist use, a definitive causal relationship has not been established