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There is a decent amount of literature showing that when people lose significant weight, some of that loss comes from muscle tissue

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(trimrx.com) Contamination is a serious concern

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Sensing the environment through sestrins: implications for cellular metabolism

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The actual weight loss averaged close to 34 pounds

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After four weeks, patients increase to 0.5mg weekly for another four weeks, then to the maintenance dose of 1mg or 2mg weekly depending on response and tolerance

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