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Therefore, we hypothesize that the imbalance in intestinal microorganisms and enzyme activity is one of the mechanisms underlying the development of diarrhea with kidney-yang deficiency syndrome

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(PubMed) Bhatnagar S, Taneja S

The common pattern: The reasoning reported by community sources for re-titrating: GI tolerance can reset during the off-cycle, and jumping back to a 2-4 mg ceiling without re-titration tends to reproduce week-1 nausea