Vitamin B12 deficiency has been associated with peripheral neuropathy and even cognitive deficits, especially in older adults and those with HIV/AIDS, where it supports nerve function and assists in the maintenance of myelin sheath integrity
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Thus, the evaluation of the link between pesticides and neurodegeneration was focused on PD, pointing out that occupational exposure to organophosphorus pesticides increases PD risk by induction of intraneuronal oxidative stress and damage, ROS-dependent oxidation of lipids and proteins mitochondrial dysfunction, ATP deficits, impaired unfolded protein response, neuroinflammation, and metabolic disruption (Fitsanakis et al., 2002)
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