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While reducing androgen levels limits hormone production, spironolactone also acts directly to protect hair follicles from DHT damage

First, severe obesity with prediabetes or T2D do not prevent the generation of HJEs and we demonstrated that these HJEs feature the cell types of an in vivo intestinal epithelium, with enterocytes, mucosecretory cells, Paneth cells and EECs, with GLP-1 cells in a controlled environment

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Before starting any new supplement regimen, patients should discuss this with their healthcare provider, particularly if considering doses above standard multivitamin levels