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[59] This gastrointestinal upset is typically most pronounced during the initial weeks of treatment and often subsides as patients continue therapy

Without sufficient protein, a significant portion of weight lost will come from muscle tissue rather than fat, which reduces metabolic rate and worsens long-term outcomes

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La hiptesis ms avalada plantea que los frmacos GLP-1 no actan sobre una sustancia especfica, sino sobre la intensidad del impulso o deseo de buscar recompensas externas