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As GLP-1R mRNA in the aortic tissue was below the level of quantification in both animal models, it seems likely that GLP-1Rs in other tissues, rather than direct action of liraglutide or semaglutide on the vascular bed, contribute to the mechanism of gene regulation

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These were generally mild to moderate in severity, most prominent during the dose escalation phase, and tended to diminish over time

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