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Hydroxocobalamin is the preferred agent in this patient population (see separate monograph in Less Common Drugs)

Abbreviations APAP : Acetaminophen GJ : Gap-junction NAC : N-acetylcysteine GSH : Glutathione NAPQI : N-acetyl-p-benzoquinone imine ROS : Reactive oxygen species Nrf2 : Nuclear factor E2-related factor 2 Cx32 : Connexin 32 TTSP : Type II transmembrane serine protease HGF : Hepatocyte growth factor References Chiew AL, Isbister GK

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24 Another study by Lenton et al 25 showed that vitamin C supplements increase glutathione in human lymphocytes

Average results seen within 12 weeks

Further supporting this combination, a 2017 study demonstrated that a retinol cream containing moisturizing ingredients, including niacinamide, caused less irritation than formulations with retinol alone