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[2] Patients should also seek medical review if constipation significantly impacts quality of life or if they find themselves increasingly reliant on stimulant laxatives

In the six months following approval (JanuaryJune 2025), new starts increased by 16% among OSA patients

This additional mechanism contributes to improved energy expenditure and fat oxidation, resulting in more pronounced and sustained weight reduction outcomes

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The phase 2 study specifically measured cravings and found significant reductions in desire for sweet foods (as early as week 4), salty foods (by week 16), and fatty foods (by weeks 12-16) at doses of 4mg and above compared to placebo