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Unlike small-molecule drugs that remain stable across broad temperature ranges, peptides depend on precise spatial arrangement to bind growth hormone secretagogue receptors

doi:10.1001/jama.2024.10333 2

Diabetes 65(1):269275

Oral amiodarone may be used for outpatient management

Since obesity is associated with an increased risk of cardiovascular disease, the ongoing SELECT study is investigating whether once-weekly semaglutide 2.4 mg will reduce the risk of having cardiovascular events in patients with overweight or obesity and with prior cardiovascular disease [61]

These effects are especially important with respect to treatment of hedonic overeating in obesity, a more recent indication of GLP1-R agonists [30, 31]