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[207] [200] [78] When TAAR1 signals via Gs-coupled receptors, intracellular cAMP increases through adenylyl cyclase activation and activates PKA and PKC, in turn phosphorylating DAT

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Nickander KK, McPhee BR, Low PA, Tritschler H

The slower release of LS from F1 compared to free LS solution would be credited to the high transition temperate of Span 60 that offers a more rigid and less permeable vesicle structure, leading to a delayed rate of drug release 57

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