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5-Amino-1MQ works by inhibiting NAMPT, an enzyme that degrades nicotinamide, thereby promoting the sustained availability of nicotinamide for NAD+ synthesis

doi: 10.1016/j.matdes.2019.108313 223 SahinKOrhanCErBDurmusASOzercanIHSahinNet al

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However large scale, robust studies in humans are needed, while it is unclear if such drugs dampen reward signalling generally in the brain raising concerns around their use in people with depression

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