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Preclinical studies in animals and human case reports have demonstrated that GLP-1 agonists can reduce alcohol consumption, Markku Lhteenvuo, MD, PhD , postdoctoral researcher with the department of forensic psychiatry at the University of Eastern Finland Niuvanniemi Hospital, and colleagues wrote

doi:10.1021/bi052483v

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Secondly, TREM2 can restore microglia homeostasis through TREM2-APOE-mediated pathway, and realize the synergistic effect of TREM2 and its ligand APOE by regulating the main transcription factors homologous to microglia (including TGF-), thus increasing TREM2-mediated phagocytosis (Wei et al., 2024)