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doi: 10.3389/fphar.2025.1602976 Received 30 March 2025 Revised 13 November 2025 Accepted 14 November 2025 Published 19 December 2025 Volume 16 - 2025 Edited by Bernd Rosenkranz, Fundisa African Academy of Medicines Development, South Africa Reviewed by Kacper Nijakowski, Poznan University of Medical Sciences, Poland Miriam Njoki Karinja, Science for Africa Foundation, Kenya Updates Copyright 2025 Mazur, Ndokaj, Salerno, Vallone, Ardan, Bietolini, Carrouel, Wilk, Sarig, Ottolenghi and Bourgeois

At high cell density, quinolones are secreted and detected by PqsR, which triggers the transcription of the phz operons, where the chorismic acid is modified into a tricyclic compound, and eventually, pyocyanin ( Figure 1 ) ( P

Alternatively, if the elevated anion gap persists despite cessation of acetaminophen and administration of N-acetylcysteine, pyroglutamic acidosis is unlikely, and an alternative diagnosis should be sought

Hypoxia preconditioning promotes the proliferation and migration of human urine-derived stem cells in chronically injured liver of mice by upregulating CXCR4