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In this regard, the GLP-1 receptor has also been identified in hepatocytes and could play a role in lowering the intrahepatocyte accumulation of fatty acids obtained through treatment with GLP-1 RAs [83,108,109,110]

For patients with more troublesome side effects, additional strategies are often necessary to manage symptoms and permit drug continuation

At Affinity Whole Health, we've seen similar results with our patients

Lifestyle interventionsmeaning trying to get someone to change their behaviorwas the most and least effective method we had

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In the SURMOUNT and SURPASS clinical programs, tirzepatide produced larger average weight loss than semaglutide