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Comment: In response to our concern that the LithoVue TM Elite Ureteroscope may be appropriately described by C1747, the applicant stated that while C1747 does describe a single-use ureteroscope, the descriptor is too broad and does not include the key featureIRP monitoringthat makes the LithoVue TM Elite Ureteroscope unique

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The tabular data were processed with the Huttenhower labs linear discriminant analysis (LDA) effect size (LEfSe) tool via the Galaxy module (v1.0) 38

In contrast, the VPA-exposed group showed substantial pathological alterations, including mitochondrial pathologies featuring cristae disorganization and membrane rupture with alternating swelling and shrinkage (Fig

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