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Level of Evidence IV This journal requires that authors assign a level of evidence to each article

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Importantly, diffuse osteoarthritis, characterized by widespread cartilage thinning, subchondral bone sclerosis, and inflammatory milieu, is a contraindication for ACI due to poor regenerative potential and high failure rates (Muthu et al., 2023

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doi:10.1016/S0140-6736(23)01053-X Sanyal AJ, Kaplan LM, Frias JP, et al

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