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it accumulates in liver cells

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Dulaglutide is a long-acting GLP-1 RA consisting of two identical disulfide-linked chains, each containing a GLP-1 analog covalently fused to the Fc fragment of a modified human immunoglobulin G4 (IgG4)

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Such adverse effects highlight the importance of careful patient selection when prescribing GLP1RA, including identifying those with prior gastrointestinal issues such as severe constipation, prior bowel obstruction or ileus

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