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(1) Dietary pattern adaptation Western populations (Europeans, Australians): the Mediterranean diet (rich in omega-3 and olive oil) reduces depression risk, as their gut microbiota (high Faecalibacterium abundance) efficiently metabolizes omega-3 into anti-inflammatory resolvins (86, 87, 331)

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22,23 Historically, varicocele has been thought to cause infertility by reducing oxygenation and increasing oxidative stress in the testicular environment, but more recent evidence also implicates inflammatory and immune mechanisms