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Its effect is gradual and appears most pronounced when combined with a caloric deficit and regular physical activity

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Graham IM, Daly LE, Refsum HM, Robinson K, Brattstrm LE, Ueland PM, Palma-Reis RJ, Boers GHJ, Sheahan RG, Israelsson B, Uiterwaal CS, Meleady R, McMaster D, Verhoef P, Witteman J, Rubba P, Bellet H, Wautrecht JC, De Valk HW, Lis ACS, Parrot-Roulaud FM, Tan KS, Higgins I, and Garcon D (1997)

The return of metabolism: biochemistry and physiology of the pentose phosphate pathway