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Patients assigned to tirzepatide showed a 20.9% BW loss after 36 weeks with an additional 5.5% reduction after 52 weeks, while those who switched to placebo experienced a 14% weight regain, confirming the findings from STEP 4 supporting the chronicity of obesity and the need for continuous treatment

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For patients managing insulin resistance and prediabetes, a therapy that simultaneously reduces VAT and improves lipid markers addresses multiple risk factors through a single hormonal mechanism

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J Virol 91(15):17 Caballero A, Katkere B, Wen XY, Drake L, Nashar TO, Drake JR, Drake JR (2006) Functional and structural requirements for the internalization of distinct BCR-ligand complexes