Cell (2017) This landmark Cell publication from Erasmus University Medical Center introduced FOXO4-DRI as a senolytic peptide that selectively eliminates senescent cells by disrupting the FOXO4-p53 interaction
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The authors reported that in obese mice, daily AOD-9604 administration over 14 days produced significant reductions in body weight gain, decreases in adipose tissue mass, and increases in fat oxidation, with effect sizes comparable to those of full-length human growth hormone [1]
[DOI] [PubMed] [Google Scholar] 48.Nguyen LH, Kudva AK, Saxena NS, Roy K
If you want the simplest possible dosing experience across the entire escalation schedule, aim for a 20mg/mL concentration regardless of vial size
A three-year trial of DHA supplementation (800 mg/day) in elderly adults without dementia is currently under way (see www.clinicaltrials.gov)