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This change makes the molecule too hydrophilic to cross BBB, therefore high dose is needed for CNS application [16]

Chemotherapy with drugs like 5-fluorouracil has also been associated with acute thiamine deficiency by disrupting thiamine activation, so oncology patients receiving such therapy might receive parenteral thiamine supplementation as part of this B-Complex if needed

For comprehensive safety information, review our guide on IV therapy safety

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These include allergic reactions ranging from mild skin reactions to potentially serious anaphylaxis (extremely rare), though true allergic reactions to glutathione itself are uncommon given its endogenous nature