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As anticipated, H-89 also inhibited the expression of Fra-1 and CCN4, which are downstream target proteins of -catenin and EMT-related factors (Fig

Esposito, The good companions: insulin and glucagon-like peptide-1 receptor agonist in type 2 diabetes

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Although ROS play essential roles in the maintenance of basal cellular activities such as chondrocyte proliferation and matrix remodeling in cartilage, excessive oxidative stress causes detrimental events such as cellular senescence 36,121 , dedifferentiation 122 , and apoptosis 123