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Glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) are two hormones responsible for the amplification of insulin secretion after nutrient consumption, and they have different actions (11)

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Also, fixed-ratio combination has the advantage of a less complex treatment regimen, with only one injection a day

They are also preferred over older diabetes medications due to their favorable effects on blood sugar regulation and their low risk of hypoglycemia (low blood sugar), as well as their proven benefit for cardiovascular risk reduction

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Randomized clinical trials are the gold standard for proving causality because they control for confounders