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Co-existence of furin with ACE2/RAAS in the female and male reproductive systems pose a potential risk on human fertility in COVID-19 patients

While both gene categories imply Ubx-RNA binding events coordinating splicing, two distinct mechanisms seem at play: the target genes regulated at both transcription and splicing levels largely depend on Ubx-DNA binding ability to regulate splicing, which cannot be dissociated from its RNA binding activity (Figure 1M)

These research findings will have profound consequences beyond academics