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1 Introduction Until recently, the worldwide increase in obesity, characterized by a body mass index (BMI) exceeding 30 kg/m 2 , was widely considered an inevitable trend with limited hope for meaningful advances in pharmacological treatment

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Mechanistically, GLP-1R signaling interacts with glutamatergic and gamma-aminobutyric acid (GABA)ergic pathways in mesocorticolimbic circuits, as well as with vagal afferents and hypothalamic networks that integrate energy balance and motivational states [8,12]

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Yes, but it can vary widely depending on the state you live in

Even though weight loss reaches a plateau after about a year or so, people who take a GLP-1 RA for weight loss might still prefer to stay on it for the long term