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Future Outlook & Research Directions Where might FOXO4-DRI go from here

The intuitive reason that GSH(t) is fairly stable is that GSH changes quite slowly when estradiol and S ( t ) vary

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Activated PKA and EPAC2 can close ATP-dependent K + channels and voltage-dependent K + channels, leading to membrane depolarization and the activation of voltage-dependent calcium channels (VDCC), resulting in Ca 2+ influx