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J Transl Med 24 , 257 (2026)

As a System X c inhibitor, Sorafenib is the only anticancer drug that causes ferroptosis in patients with HCC (Louandre et al., 2013)

Nausea/vomiting: Peaks week 1-2, eases with food or slower titration

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Native IGF-1 is rapidly sequestered by IGF-binding proteins (IGFBPs) in the circulation, resulting in a half-life of approximately 1020 minutes