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TB-500 affects cytoskeleton dynamics and cell migration (structural side), while BPC-157 modulates angiogenesis, neurotransmission, and cell adhesion (signaling side)

FDA Adds Several Peptides to Category 2 Bulks List, Restricting Them From Compounding On September 29, 2023, updates were made to the list of bulk drug substances nominated for use under Section 503A

doi: 10.1038/ni.2422 106 AbtMCOsborneLCMonticelliLADoeringTAAlenghatTSonnenbergGFet al

F.Haldor HansenT.VinbergM.KessingL

Storage matters more here than it does for a robust small molecule, because peptides are fragile: heat, light, agitation and freeze-thaw cycles all degrade them, and a degraded peptide simply under-delivers with no visible warning

To this end, GSSSG or GSSG was intravitreally administered to rat eyes together with LPS, and changes in the expression of proinflammatory genes were analyzed at 10 h post-administration by RT-qPCR