Choose Retatrutide If: Maximum weight loss is the primary goal Previous GLP-1 agonists produced significant nausea (GIP component may help) No specific liver health concerns requiring treatment Tolerance for slightly higher GI side effects during titration Response to dual agonists (like tirzepatide) has been positive Choose Survodutide If: Liver health concerns exist (fatty liver, MASH, elevated liver enzymes) Moderate weight loss goals rather than maximum efficacy priority Interest in potential cardiovascular outcome benefits (CVOT data pending) Preference for a compound with FDA Breakthrough Therapy designation Plans to potentially transition to approved medication once available For most people focused primarily on weight loss, Retatrutide presents the stronger option based on available data

For those who want targeted nutritional support alongside their tirzepatide protocol, our guide to supplements to take with tirzepatide covers evidence-based options beyond the B6 already included in BPI Labs formulations
Diabetologia 66(10):17651779 Liu QK (2024) Mechanisms of action and therapeutic applications of GLP-1 and dual GIP/GLP-1 receptor agonists
Coverage for weight loss medications is still hit or miss, but if your plan does cover GLP-1s for weight management, itll cover the Wegovy pillnot Ozempic
Ertekin A, Deer Y, Mert H, Mert N, Yur F, Dede S, et al
Has appetite suppression become excessive