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, a bioactive compound that has an inhibitory effect on melanin (the pigment that gives color to the skin) synthesis (5)

Complying with these requirements can increase the likelihood of approval

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Avoid products that contain soy, artificial sweeteners, or "natural flavors" that aren't clearly defined

doi:10.1016/j.dsx.2025.103238 167

The mechanism is likely multifactorial: delayed gastric emptying, heightened visceral sensitivity, and alcohol's own irritant effect on the stomach lining all play a role