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While not FDA-approved specifically for weight loss, metformin typically produces modest weight reduction of 1-3 kg (approximately 2-3% of body weight), possibly through decreased appetite, potential effects on gut microbiome composition, and metabolic effects on cellular energy pathways

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[DOI] [PubMed] [Google Scholar] 28.Spiegelman B.M

Switching between oral and injectable GLP-1s is possible and commonly done based on clinical results, tolerability or insurance coverage

Food groups and risk of type 2 diabetes mellitus: a systematic review and meta-analysis of prospective studies

Lancet Gastroenterol Hepatol Mantelmacher FD, Fishman S, Cohen K et al (2017) Glucose-dependent insulinotropic polypeptide receptor deficiency leads to impaired bone marrow hematopoiesis