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Ferroptosis and Cancer Genes RAS The RAS family of small GTPase, including HRAS, NRAS, and KRAS, is closely related to ferroptosis since the two most well-known ferroptosis inducers, erastin (eradicator of RAS and ST) and RSL3 (RAS-selective Lethal 3), are technically oncogenic RAS-selective lethal small molecules (Yagoda et al., 2007

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Fitzcharles-Bowe et al, 2007)