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Several trials and updated analyses indicate improvements in fasting insulin, HOMA-IR, BMI/waist indices, and lipid parameters, particularly among women with obesity or IR and low baseline 25(OH)D, whereas pooled estimates from other RCTs fail to show consistent effects on fasting glucose or HOMA-IR, likely reflecting underpowered studies and short follow-up (118)

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Effect of Combinations of ALA and Other Compounds on Female Pathologies: Clinical Studies A recent systematic review investigated the potential benefits of ALA in women with polycystic ovary syndrome (PCOS) and confirmed the improvement of different cardiometabolic factors (such as fasting blood sugarFBS and HOMA-IR) as well as hormonal parameters [148]

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