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In the opposite direction, afferents from various hypothalamic nuclei project to the olfactory system 44,45

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Tirzepatide works by activating GLP-1 and GIP receptors in your brain, creating powerful satiety signals that make food feel less appealing

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Cell metabolism , 2023, 35.9: 1519-1529

[28] [29] Before starting GLP-1 therapy, your healthcare provider will: Review your complete medical history, including thyroid disease status Ensure thyroid function is optimised Assess for any contraindications Discuss the benefits and risks specific to your situation With appropriate patient selection and monitoring, GLP-1 receptor agonists can be safely prescribed to individuals with Hashimoto's disease when the clinical benefits outweigh potential risks