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From the bloodstream, it acts on melanocortin receptors (receptors in cells that play a role in pigmentation, among other functions), resulting in enhanced skin pigmentation or tanning (3)
Parr C, Ali AY
For women, especially post-menopause or post-partum, the drop in estrogen and progesterone directly accelerates collagen loss (as quickly as 30% in the first five years after menopause!)
Free Rad Biol Med 2002
23, Novo Nordisk released late-stage study results showing participants who took its next-generation obesity drug, CagriSema, didnt lose quite as much weight (23%) as those who took rival Eli Lillys Zepbound (25.5%)
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