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In dulaglutide, two modified DPP-4-resistant GLP-1 molecules are each fused to a modified F C fragment of human immunoglobulin 4 via a small peptide (Fig

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sCT when bound to AMYRs induce a CT-like receptor conformation 15 , while P32Y substitutions of CT analogues are also detrimental to affinity and potency at AMYRs 18,19

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