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These are distinct from injection site reactions because they can appear anywhere on the body

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This is of high physiological and clinical importance as it is in the microcirculation where substrate and oxygen delivery and extraction take place and a relatively small increase in the microvascular surface area could markedly increase substrate and oxygen extraction by the tissue (skeletal muscle and myocardium), particularly in the presence of limited total blood flow, as seen in humans with T2DM and atherosclerosis