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The typical approach is to start low and titrate up gradually to reduce the risk of gastrointestinal side effects

For joints specifically, it is a repair assist, not a cure for arthritis

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Liver fat reduction and metabolic health Weight loss is not the only reason people consider the switch

They result from slowed gastric emptying allowing bacterial fermentation in the stomach, and the change in gastric motility patterns during medication transitions can exacerbate them temporarily

doi: 10.1152/ajpcell.00188.2022 48