This foundational discovery later recognized with the 2024 LaskerDeBakey Clinical Medical Research Award for Habener, Mojsov, and Lotte Bjerre Knudsen laid the foundation for an entirely new class of GLP-1 medications.[1] Gut releases natural GLP-1 that is destroyed in the bloodstream within about two minutes by the enzyme DPP-4 that is a widely distributed integral membrane protein that is expressed in the intestine, kidney, vascular endothelium, liver pancreas, glandular epithelial cells, and immune system cells.[17] Hence, DPP-4 inhibitors are a successful class of anti-hyperglycaemic agents used to treat type 2 diabetes (T2DM) via protecting GLP-1
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The duration of treatment varies depending on your weight loss goals and response to the medication
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Adam Wolfe, an internal medicine specialist with University of Michigan Health-West Hospital, told Fox News Digital in an interview
## Liraglutide (Saxenda / Victoza): The Established Veteran Liraglutide was the first GLP-1 approved for weight management and remains in use, though it has been largely superseded by newer options