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For DRG, trigeminal ganglion and nodose ganglion, tissues were extracted and fixed for 12 h in 4% PFA and transferred to 30% sucrose overnight at 4 C

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The best studied one is the increase of the VEGF pathway (Vascular Endothelial Growth Factor), indicating the production of new blood vessels (angiogenesis)

This analysis excluded patients from STEP 4 as these were treated with semaglutide during the run-in phase