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Although weight loss is not its original intention, Ozempic can be prescribed off-label for weight loss by physicians for patients who qualify for a medical weight loss medication

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The blockade of GIP signaling or GIPR deficiency reduced the accumulation of T regulatory cells in the adipose tissue and significantly reduced proinflammatory-related factors in the hypothalamus of high-fat diet-fed C57BL/6J male mice [45, 46]

Notably, 84% of participants had a BMI 35 kg/m, placing them in the Class II or Class III obesity categories