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These findings suggest that SRB overgrowth and exogenous HS accumulation are closely linked to IBD pathogenesis and are strongly correlated with disease severity

Circadian disruption in beta-Bmal1(-/-) mice and arrhythmic Clock 19 mice decrease the Nrf2 expression and subsequently impair the antioxidant defense system, contributing to increased ROS accumulation, oxidative damage and mitochondrial uncoupling

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Motta F, Bizzaro N, Giavarina D, Franceschini F, Infantino M, Palterer B, et al