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The estimated treatment ratios of the mean AUC 0 of cagrilintide in each of the renal impairment groups to the normal renal function group were 1.23 (90% CI, 0.911.66) for the mild renal impairment group, 1.18 (90% CI, 0.871.59) for the moderate renal impairment group and 1.21 (90% CI, 0.871.68) for the severe renal impairment group

You are already past the initial GLP-1 titration phase, so adding HRT is straightforward

Review rat study data, NO pathway mechanisms, and safety considerations.

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doi: 10.1016/j.fct.2005.11.003 235