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The expression of GSTs and the ratio of GSSG to total glutathione were suggested as early indicators of the presence of the esca disease in grapevine canes (Valtaud et al., 2009

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However, there is a problem in that the activity of GRK2 affects angiogenesis in various ways in different diseases, including in different subtypes and different stages of progression of the same disease, such as in cancers (3, 42, 61)

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