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Guan J, Watrelot A

If proper titration starting at the lowest dose with gradual 4-week escalation still produces intolerable GI effects, split dosing may allow continued use of the medication rather than abandoning it entirely

10.3389/fpls.2016.00065 Front

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It attaches itself to a brain receptor called GABA-A (Gamma-AminoButyric Acid-A)