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The incidence of fetal malformations in liraglutide-treated groups exceeding concurrent and historical controls were misshapen oropharynx and/or narrowed opening into larynx at 0.1 mg/kg/day and umbilical hernia at 0.1 and 0.25 mg/kg/day

Cyclisation restricts backbone conformational freedom and confers marked resistance to proteolysis relative to linear analogues, which is why melanotan 2 became a standard reference agonist rather than a research curiosity

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Adv Sci (Weinh) 10:e2301868

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